Security forces stormed Urman Park, where a number of pro-Morsi protesters were holed up after their sit-in was forcibly dispersed earlier in the day.
According to eyewitnesses, fire had spread from burning tents and tires in the square to several parked cars.
Vehicles passing in nearby streets, meanwhile, are reportedly being searched for fleeing Muslim Brotherhood leaders and weapons.
Protests flare up in Egypt provinces after deadly Cairo sit-in dispersal
Demonstrations erupted in several Egyptian provinces on Wednesday to protest the violent dispersal of two major sit-ins held by supporters of ousted President Mohamed Morsi in Cairo and Giza.
In the canal city of Suez, dozens of pro-Morsi supporters assembled outsize the Hamza Hospital and blocked Nasser Road with burning tires.
A march also set out towards the Suez governor's office with demonstrators chanting slogans against military chief Gen Abdel Fattah al-Sisi, an Anadolu Agency correspondent reported.
In Suez, army forces stepped up security around the governor's office, government offices, police stations and the local security directorate.
The moves came hours after security forces moved in to disperse two pro-democracy sit-ins in Cairo's Rabaa al-Adawiya Square and Giza's Nahda Square.
Sources at the sit-in camps said that at least 163 people had been killed and over 7,000 injured in the forcible dispersal of the two sit-ins.
The violent dispersal has spurred angry protesters to take to the streets in several Egyptian provinces.
In the Nile Delta province of Sharqiya, dozens of angry demonstrators cut off a main road in protest of the killings.
In Beheira, hundreds of Muslim Brotherhood members clashed with security forces outside the governor's office. Security forces reportedly fired birdshot at protesters.
In Upper Egypt, protesters surrounded the governor's office in Aswan, while roads were reportedly blocked in the Luxor and Sohag provinces.
Angry demonstrators in Beni Sueif torched two cars as they prepared for a protest against the police assault on Morsi supporters in Cairo and Giza.
On the other hand, in the coastal city of Alexandria, a number of Morsi supporters converged on a main square to protest the deadly dispersal of the two Cairo sit-ins.
According to eyewitnesses, protesters gathering at Rabaa al-Adawiya Square in downtown Alexandria (not to be confused with the square in Cairo of the same name) chanted slogans against the Interior Ministry and blocked the vital cornice road in both directions.
Meanwhile violence started to spread across Egypt as three churches in Upper Egypt were targeted in arson attacks by unidentified men, according to eyewitnesses.
A group of unidentified arsonists hurled Molotov cocktails at the churches of Anba Abraam and Virgin Mary in Deir Mawas, Minya, causing minor damage to their facades.
A separate fire-bomb attack targeted the clinic building affiliate to Saint Menas Church in Minya.
A third church was subject to a similar attack in Sohag province, eyewitnesses said.
There was no immediate statement from the authorities on the incidents, and it is still unclear whether the attacks are connected to the violent dispersal of two major sit-ins by supporters of ousted president Mohamed Morsi, which left hundreds dead and injured.
